Frey syndrome is characterized by unilateral flushing and sweating of the facial skin innervated by the auriculotemporal nerve (neck, parotid region, and. A neurologist from Poland, Dr. Lucja Frey, provided a detailed assessment of the disorder and coined the term “auriculotemporal syndrome” in Auriculotemporal nerve syndrome, also known as Frey syndrome, is an uncommon clinical entity in children. It is widely thought to be the result.

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Sign in to access your subscriptions Sign in to your personal account. Hence recognition of Frey syndrome in pediatric population is very important to avoid misdiagnosis as food allergy.

Botulinum toxin A in the treatment of patients with Frey syndrome.

Frey’s syndrome – Wikipedia

Standard Therapies Treatment Although Frey syndrome can be mild and well-tolerated, in some individuals, it can cause excessive discomfort. More recent studies, which objectively measured flap thickness and assessed Frey syndrome by clinical symptoms as well as starch-iodine testing, have failed to demonstrate a reduction in the incidence of Frey syndrome with increased flap thickness.

Although intraoperative techniques try to reduce severity and incidence of Frey syndrome, postoperative interventions have been focused on ameliorating symptoms once they develop.

In adults, it is common following parotid surgery. The other auriculotrmporal etiologic factors aruiculotemporal parotitis, mandibular condylar fracture, blunt trauma, herpes zoster, associated central nervous system disorders such as syringomyelia, epilepsy, and meningioma of the cerebellopontine angle tumor. Surgical treatment for Frey syndrome refractory to medical auriulotemporal has been described, but clinical data to support its utilization are limited.

Auriculotemporal Syndrome (Frey Syndrome).

For more information on this disorder, choose the specific disorder name as your search term aurivulotemporal the Rare Disease Database. Frey syndrome is due to the misdirected regenerative process of the auriculotemporal nerve. Tests with acetylcholine, pilocarpine, and histamine in one patient led to the conclusion that, in the process of recovery from parotitis, regenerating parasympathetic salivary fibers must have been misdirected into the sweat glands, which normally have a sympathetic innervation, and that these responded thereafter in a manner to be expected from their abnormal, dual nerve supply.


This is sometimes termed “gustatory neuralgia”. Beerens A, Snow G.

Powered By Decision Support in Medicine. In very limited studies, there have been reports that abdominal fat implantation decreases the occurrence of Frey syndrome.

Journal of Oral and Maxillofacial Surgery. An unusual variant presenting as gustatory flushing mimicking food allergy”. Yu L, Hamilton R. A neurologist from Poland, Dr. Related Disorders Symptoms of the following disorders can be similar to those of Frey syndrome. In addition, ADM represents a suitable alternative to local fascia and muscle flaps for the prevention of Sydnrome syndrome. It described sweating and flushing in the preauricular area in response to mastication or a salivary stimulus.

Initial results have demonstrated that this auriculotemopral results in the suppression of sweating and causes no significant side effects.

Auriculotemporal Syndrome (Frey Syndrome)

For those who develop clinical symptoms of Frey syndrome, objective testing can be performed with a Minor starch-iodine test. Otolaryngologic Clinics of North AmericaVol.

Then, a starch powder such as corn starch is applied over the iodine solution. The percentage of individuals who develop Frey syndrome after a parotidectomy is controversial and reported estimates range from percent. The temporoparietal fascia flap TPFF is a broad, vascularized fascia flap that is based off the superficial temporal artery Fig.

The subsequent regeneration or nerve sprouting leads to abnormal sweating and salivating. Autologous and biosynthetic material have been used to create the physical barrier between the transected parotid and the overlying cutaneous tissues. Frey syndrome is a rare disorder that most often occurs as a result of surgery in the area near the parotid glands. Arch Facial Plast Surg.


In addition, the TPFF allowed for improved cosmetic outcome because it reduced the contour defect. Subcutaneous injection auriculottemporal botulinum toxin A into affected areas can be used to treat the postoperative symptoms of Frey syndrome. Segmental flushing after ingestion of fruit snacks.

Prevention of Frey syndrome has been guided by the alteration auricklotemporal surgical techniques or the addition of procedures focused on preventing synkinesis. Normally, damaged nerve fiber s eventually heal themselves regenerate.

Our website uses cookies to enhance your experience. Once dry, dry starch is then applied to the painted area, and a salivary stimulus is given. A diagnosis of Frey syndrome is made based upon identification of characteristic symptoms, a detailed patient history, a thorough syndroje evaluation and a specialized test called the Minor Iodine-Starch Test.

Both patients were relieved permanently of this annoying syndrome by intracranial division of the glossopharyngeal nerve. In adults, Frey syndrome occurs mostly after parotid surgery, especially after excision of the superficial lobe or drainage of a parotid abscess. Reports in the literature have supported that the use of an SCM muscle flap decreases the incidence of Frey syndrome.

Which of the following stndrome describes your experience with hand-foot-and-mouth disease? Botulinum toxin in the treatment of autonomic nervous system disorders. J Plast Reconstr Aesthet Surg. Symptoms are often mild and well-tolerated. The affected area of the face is painted with iodine which is allowed to dry, then dry corn starch is applied to the face.